Internationally acknowledged expertise in kinase research
Olsen BB et al (2012) Characterization of ATM and DNA-PK wild-type and mutant cell lines upon DSB induction in the presence and absence of CK2 inhibitors. Int J Oncol. 40, 592-8.
Ahmed K et al (2011) Protein kinase CK2: a catalyst for biology, medicine and structural biochemistry. Mol Cell Biochem. 356, 1-3.
Raaf J et al (2011) Interaction between CK2α and CK2β, the subunits of protein kinase CK2: thermodynamic contributions of key residues on the CK2α surface. Biochemistry 50, 512-22.
Olsen BB et al (2010) Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells. Oncogene 29, 6016-26.
Niefind K & Issinger OG (2010) Conformational plasticity of the catalytic subunit of protein kinase CK2 and its consequences for regulation and drug design. Biochim Biophys Acta 1804, 484-92.
Niefind K et al (2009) Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights. Cell Mol Life Sci. 66, 1800-16.
Raaf J et al (2009) First inactive conformation of CK2 alpha, the catalytic subunit of protein kinase CK2. J Mol Biol. 386, 1212-21.
Boldyreff B et al (2008) Expression and purification of PI3 kinase alpha and development of an ATP depletion and an alphascreen PI3 kinase activity assay. J Biomol Screen. 13, 1035-40.
Olsen BB et al (2008) Exploring the intramolecular phosphorylation sites in human Chk2. Mutat Res. 646, 50 Seeber S et al (2005) Validation of protein kinase CK2 as an oncological target. Apoptosis 10, 875-885.
Boyd SM, Turnbull AP and Walse B (2012) Fragment library design considerations. WIREs Comput. Mol. Sci., in press.
Turnbull AP, Boyd SM (2012) Targeting cancer using fragment based drug discovery. Anticancer Agents Med Chem. 12, 40-8.
van Linden OP et al (2012) Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase. Eur J Med Chem. 47, 493-500.
Verheij MH et al (2011) Fragment library screening reveals remarkable similarities between the G protein- coupled receptor histamine H4 and the ion channel serotonin 5-HT3A. Bioorg Med Chem Lett. 21, 5460-4.
Edink E et al (2011) Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis. J Am Chem Soc. 133, 5363-71.
de Kloe GE et al (2010) Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands. J Med Chem. 53, 7192-201.
de Kloe GE, Bailey D, Leurs R, de Esch IJ (2009) Transforming fragments into candidates: small becomes big in medicinal chemistry. Drug Discov Today 14, 630-46.